Textbook of Molecular Medicine

Contents: 

Part 1: CELL DEATH

Pharmacological manipulation of cell death: clinical applications in sight? • Pharmacological manipulation of Bcl-2 family members to control cell death • Caspases: Pharmacological manipulation of cell death • IKK/NF-KB signaling: balancing life and death - a new approach to cancer therapy • Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function • The survival kinases Akt and Pim as potential pharmacological targets • Mitochondria: pharmacological manipulation of cell death • Death  versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways • Autophagy in cell death: an innocent convict? • Endoplasmic reticulum stress: cell life and death decisions.

PART 2: ONCOLOGY

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors •  Integrins in invasive growth •  Stat proteins and oncogenesis •  The cadherin-catenin adhesion system in signaling and cancer •  Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence •  When cells get stressed: an integrative view of cellular senescence •  Telomeres, stem cells, senescence, and cancer •  Bmi1, stem cells and senescence regulation? Cellular senescence in cancer treatment: friend or foe?? Mechanisms for pituitary tumorigenesis: the plastic pituitary •  Melanoma genetics and the development of rational therapeutics •  Immunopathogenesis and therapy of cutaneous T cell Iymphoma •  Cancer vaccines: progress reveals new complexities

PART 3: IMMUNE SYSTEM and IMMUNE-MEDIATED INJURY

IFNs and STATs in innate immunity to microorganisms •  Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways? An integrated view of suppressor T cell subsets in immunoregulation • CD4+ Tregs and immune control •  Tregs and allergic disease • Tregs and transplantation tolerance • C-reactive protein: a critical update • New insights into atopic dermatitis  • Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities •  Exploiting dendritic cells to improve vaccine efficacy

PART 4: INFECTIOUS DISEASES

Clinical syndromes: The enigma of sepsis  • Gram-positive bacteria in health and disease: Antimicrobial resistance: the example of Staphylococcus aureus  • Bacterial infectious disease control by vaccine development  • Development of an improved vaccine for anthrax  • Gram-negative bacteria in health and disease : Helicobacter pyloripersistence: biology and disease  • The emergence of Lyme disease  • Bacterial communication: The application of biofilm science to the study and control of chronic bacterial infections  • Quorum sensing in Staphylococcus infections  • Quorum sensing and biofilm formation in Streptococcal infections  • Pharmacological inhibition of quorum sensing for the treatment of chromic bacterial infections • Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target  • Protozoal infections : Antimalarial drug resistance  • Parasitic infections  • Human African trypanosomiasis of the CNS: current issues and challenges 

PART 5: VIRAL DISEASES

SARS coronavirus: a new challenge for prevention and therapy  • Acute HIV revisited: new opportunities for treatment and prevention  • Strategies for an HIV vaccine  • Dengue: defining protective versus pathologic immunity  • West Nile virus: a growing concern?  • Progress on new vaccine strategies against chronic viral infections • Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease • Influenza vaccines: present and future • Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics • Herpes simplex viruses: is a vaccine tenable? • Prophylactic human papillomavirus vaccines 

PART 6: RESPIRATORY SYSTEM

Disorders of lung matrix remodeling • New insights into the pathogenesis of asthma • JAK-STAT signaling in asthma • Rescuing protein conformation: Prospects for pharmacological therapy in cystic fibrosis • Epithelial-mesenchymal transition and its implications for fibrosis

PART 7: CARDIOVASCULAR SYSTEM 

Oxygen, oxidative stress, hypoxia, and heart failure  • NO/redox disequilibrium in the failing heart and cardiovascular system  • Genetic causes of human heart failure  • Protein kinase cascades in the regulation of cardiac hypertrophy  • Toward transcriptional therapies for the failing heart: chemical screens to modulate genes  • Mitochondrial energy metabolism in heart failure: a question of balance  • Death begets failure in the heart  • Unchain my heart: the scientific foundations of cardiac repair  • Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities  • Sex is a potent modifier of the cardiovascular system • Vascular diseases: Cholesterol in health and disease  • Cholesterol, lipid rafts, and disease  • Malformation syndromes due to inborn errors of cholesterol synthesis  • Intracellular cholesterol transport  • Regulation and mechanisms of macrophage cholesterol efflux • Consequences of cellular cholesterol accumulation: basic concepts and physiological implications  • Monogenic hypercholesterolemia: new insights in pathogenesis and treatment  • Isoprenoids as mediators of the biological effects of statins  • Disorders of rhythm: The channelopathies: novel insights into molecular and genetic mechanisms of human disease  • Mechanisms of sudden cardiac death  • Long QT syndrome: from channels to cardiac arrhythmias  • Genetics of acquired long QT syndrome  • Muscle channelopathies and critical points in functional and genetic studies  • Inherited disorders of voltage-gated sodium channels  • Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2 + release channels • Chloride channel diseases resulting from impaired transepithelial transport or vesicular function 

PART 8:HEMATOLOGY

Megakaryocyte biology and related disorders  • The molecular mechanisms that control thrombopoiesis • Thrombus formation in vivo  • Platelet genomics and proteomics in human health and disease  • The biogenesis of platelets from megakaryocyte proplatelets • Platelets in inflammation and atherogenesis  • Structure and function of the platelet integrin aIIb??3 • Minding the haps to promote thrombus growth and stability • Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood

PART 9: GASTROINTESTINAL SYSTEM

Intestinal ion transport and the pathophysiology of diarrhea • Molecular mediators of hepatic steatosis and liver injury • Liver Fibrosis • SREBPs: activators of the complete program of cholestrol and fatty acid synthesis   in the liver

PART 10: ENDOCRINOLOGY AND METABOLISM

Genetic epidemiology of diabetes • ATP-sensitive potassium channelopathies: focus on insulin secretion • Gestational diabetes mellitus • Regeneration of the pancreatic ?? cell • Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus • How does blood glucose control with insulin save in intensive care?  • Thyrotropin receptor-associated diseases: from adenomata to Graves disease • Inflammation, stress, and diabetes • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome • The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa • Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface 

PART 11: KIDNEY AND URINARY TRACT

Acute renal failure: definitions, diagnosis, pathogenesis, and therapy • Kidney stone disease • Salt handling and hypertension

PART 12: BONE AND MINERAL METABOLISM • Pathogenesis of osteoporosis: concepts, conflicts and prospects • Paget disease of bone • Estrogen deficiency and bone loss: an inflammatory tale • Regulation of bone mass by Wnt signaling 

PART 13:  NEUROLOGIC DISORDERS

VEGF: A critical player in neurodegeneration • Neurogenesis and brain injury: managing a renewable source for repair • Oxidative stress, cell cycle, and new degeneration • The role of cerebral amyloid ?? accumulation in common forms of Alzheimer disease • Alzheimer disease therapy: Can the amyloid cascade be halted? ?

Diagnosis and treatment of Parkinson disease: molecules to medicine • Huntingtin in heath and disease • Programmed cell death in amyotrophic lateral sclerosis • Multiple sclerosis • Progress and problems in the biology, diagnostics, and therapeutics of prion diseases • The genetic epidemiology of neurodegenerative disease • Sodium channel mutations in epilepsy and other neurological disorders • Finding schizophrenia genes • The addicted human brain: insights from imaging studies

PART 14: GENETICS AND DISEASE

Mapping the new frontier • complex genetic disorders • Mapping quantitative trait loci in humans: achievements and limitations • Linkage disequilibrium maps and association mapping • Genetic counselors: translating genomic science into clinical practice • Genetic counseling throughout the life cycle • Payment of clinical research subjects • Embryonic death and the creation of human embryonic stem cells • Stem cells: science, policy, and ethics

About the Editor: 

Andrew R. Marks, Editor in Chief, The Journal of Clinical Investigation, at Columbia University College of Physicians and Surgeons, New York, USA.